U.S. President Donald Trump and first lady Melania Trump hosted thousands of children and their parents Monday at the White House for the annual Easter Egg Roll.

The president, first lady and their 11-year-old son Barron, accompanied by an Easter Bunny, greeted the crowd from a balcony of the White House. “We will be stronger and bigger and better as a nation than ever before,” Trump said. “We’re right on track. You see what’s happening.”

The Easter Egg Roll at the White House, on the day after Easter, has a long tradition dating back to 1878.

This year’s event, with 21,000 tickets handed out to Washington-area schoolchildren and military families, was a smaller affair than in years past. About 35,000 people attended a year ago, when then-first lady Michelle Obama organized a carnival-like affair with pop singers, celebrity chefs and professional sports stars.

Children and families roamed the White House lawn at Monday’s event, pushing wooden eggs across the grass with oversized spoons, playing beanbag games and coloring drawings that are being sent to U.S. troops stationed overseas. Military bands, a pop-rock band and a family circus performed for the crowd.
…

From: MeNeedIt

The challenge of finding a cure for AIDS may have gotten harder. Scientists have discovered another cell in the body where HIV — the virus that causes AIDS — hides from therapy designed to suppress it to undetectable levels in the blood.

The cells — called macrophages — are part of the immune system and are found throughout the body, including in the liver, lungs, bone marrow and brain. After other immune cells have done their job of destroying foreign invaders, these large white blood cells act as the cleanup crew. They surround and clean up cellular debris, foreign substances, cancer cells and anything else that is not essential to the functioning of healthy cells. In addition, they apparently can harbor HIV.

A new target

While antiretroviral drugs can drive the AIDS virus down to virtually undetectable levels, scientists know if therapy is interrupted, an HIV infection can come roaring back. That’s because of a viral reservoir that until now has been thought only to inhabit immune system T-cells — the cells that are attacked and destroyed by the AIDS virus. Much research is dedicated to trying to find ways to eradicate the T-cell reservoir.

This may mean researchers must find ways to eliminate HIV from macrophages, as well.

The finding was published in Nature Medicine by researchers in the Division of Infectious Diseases at the University of North Carolina School of Medicine. 

Investigators demonstrated in a mouse model that in the absence of humanized T-cells, antiretroviral drugs could strongly suppress HIV in macrophages. However, when the therapy was interrupted, the virus rebounded in one-third of the mice. This, say researchers, is consistent with persistent infection in the face of drug therapy.

Researchers say their work demonstrates that any possible therapies must address macrophages, in addition to T-cells, to eradicate viral reservoirs.

The lead author of the study, Jenna Honeycutt, called the discovery “paradigm changing” in the way scientists must now try to eliminate persistent infection in HIV-positive individuals. 

Investigators say their next step is to figure out what regulates HIV persistence in infected macrophages. They are also interested in finding HIV interventions that completely eradicate the AIDS virus from the body.
…

From: MeNeedIt

Mini motorcycle and go-kart maker Monster Moto made a big bet on U.S. manufacturing by moving assembly to this Louisiana town in 2016 from China.

But it will be a long ride before it can stamp its products “Made in USA.”

The loss of nearly one out four U.S. factories in the last two decades means parts for its bike frames and engines must be purchased in China, where the manufacturing supply chain moved years ago.

“There’s just no way to source parts in America right now,” said Monster Moto Chief Executive Alex Keechle during a tour of the company’s assembly plant. “But by planting the flag here, we believe suppliers will follow.”

Monster Moto’s experience is an example of the obstacles American companies face as they, along with President Donald Trump, try to rebuild American manufacturing. U.S. automakers and their suppliers, for example, have already invested billions in plants abroad and would face an expensive and time-consuming transition to buy thousands of American-made parts if President Trump’s proposed “border tax” on imported goods were to become law.

When companies reshore assembly to U.S. soil – in Monster Moto’s case that took two years to find a location and negotiate support from local and state officials – they are betting their demand will create a local supply chain that currently does not exist.

For now, finding U.S.-based suppliers “remains one of the top challenges across our supplier base,” said Cindi Marsiglio, Wal-Mart Stores Inc.’s vice president for U.S. manufacturing and sourcing. Wal-Mart partnered with Monster Moto and several other U.S. companies in a drive to increase spending on American-made goods by $250 billion by 2023 in response to consumer demand for American-made goods.

Their experience has shown Americans’ patriotic shopping habits have limits, namely when it comes to price.

Take Monster Moto’s bikes, which sell for between $249 to $749. Keechle, the CEO, says he can’t raise those prices for fear his price sensitive prospective customers will turn to less expensive rivals made in China.

“Consumers won’t give you a free pass just because you put ‘Made in USA’ on the box,” Keechle says. “You have to remain price competitive.”

Keeping a sharp eye on labor costs in their factory is one thing these U.S. Manufactures can control. They see replacing primarily lower-skilled workers on the assembly line with robots on American factory floors as the only way to produce here in a financially viable, cost-competitive way. It’s a trend that runs against the narrative candidate Donald Trump used to win the U.S. presidency.

Since taking office, Trump has continued promises to resurrect U.S. manufacturing’s bygone glory days and bring back millions of jobs. On March 31, Trump directed his administration to clamp down on countries that abuse trade rules in a bid to end to the “theft of American prosperity.”

But it’s more complicated on the ground for companies like Monster Moto.

“It’s almost as if people think you can just unplug manufacturing in one part of the world and plug it in to the U.S. and everything’s going to be fine,” said David Abney, Chief Executive Officer of package delivery company United Parcel Service Inc., which helped Monster Moto reconfigure its supply chain to bring its Chinese-made parts to Ruston.

“It’s not something that happens overnight,” he said.

A White House official said that the Trump administration’s efforts to encourage manufacturers to reshore production will be focused on cutting regulations and programs to provide new skills to manufacturing workers.

“We recognize that the manufacturing jobs that come back to America might not all look like the ones that left,” a White House official said, “and we are taking steps to ensure that the American workforce is ready for that.”

Making robots great again

In Monster Moto’s cavernous warehouse in Ruston, boxes of imported parts that are delivered at one end then become bikes on a short but industrious assembly line of a few dozen workers.

A solitary, long-bearded worker by the name of Billy Mahaffey fires up the bikes to test their engine and brakes before a small group of workers puts them in boxes declaring: “Assembled in the USA.”

Helped by that label, Monster Moto has experienced a recent boom in demand from major customers that include Wal-Mart. The company expects to double production to 80,000 units and increase its assembly workers — who make $13 to $15 an hour — to 100 from around 40 in 2017.

The most likely components Monster Moto could produce in America first are black, welded-metal frames for bikes and go-karts, but they would have to automate production because human welders would be too expensive.

“We can’t just blow up our cost structure,” said Monster Moto President Rick Sukkar. “The only way to make it work in America is with robotics.”

The same principle applies for much larger manufacturers, such as automotive supplier Delphi Automotive PLC’s.

Chief Financial Officer Joe Massaro told analysts in February that 90 percent of the company’s hourly workforce is in “best-cost countries.”

When asked about shifting production to the United States from Mexico, Massaro said depending on what happens to trade rules “it would have to be much more of the sort of the automated type manufacturing operations just given… the labor differential there.”

That trend is already showing up in data compiled by Economic Policy Institute, a Washington-based think tank.

According to senior economist Rob Scott, not only did America lose 85,000 factories, or 23.5 percent of the total, from 1997 to 2014, but the average number of workers in a U.S. factory declined 14 percent to 44 in 2014 from 1997. According to Scott, much of the decline in workers was due to automation.

“We’re going to see more automation in this country because it makes good sense economically for every company,” said Hal Sirkin, a managing director at the Boston Consulting Group. “You can spend a lot of time bemoaning it, but that’s not going to change.”

Manufacturers say automated production requires fewer, but more skilled workers such as robot programmers and operators.

The National Association of Manufacturers (NAM) estimates because of the “skills gap” there are 350,000 unfilled manufacturing jobs today in a sector that employs over 12 million people.

In Ruston, Mayor Ronny Walker bet on Monster Moto by guaranteeing the company’s lease because he wants to diversify the city’s economy, and envisions suppliers setting up alongside Monster Moto’s assembly plant.

“Could it take a long time to bring manufacturing back here?

Sure,” he says. “But you have to start somewhere.”
…

From: MeNeedIt

China’s economic recovery is gaining traction, with growth rising to its fastest pace in over a year in January-March.

The 6.9 percent annual pace of expansion for the world’s second-largest economy, reported Monday, surpassed economists’ forecasts and was an improvement from 6.8 percent growth in the last quarter of 2016.

Growth last was that strong in July-September of 2015.

Analysts said government spending and a property boom spurred by easy credit were the main factors helping to driving stronger demand.

China saw its slowest growth in nearly three decades in 2016, at 6.7 percent. The official full-year economic growth target for 2017 is 6.5 percent.

“Currently, China’s economy is demonstrating good signs of pickup in growth, overall price stability, expansion in employment and improvement in the international balance of payments,” Mao Shengyong, a spokesman for the National Bureau of Statistics, told reporters in Beijing.

Fears of being dragged into a trade and currency war with the U.S. have abated after U.S. President Donald Trump toned down his previously antagonistic comments against Beijing.

A summit earlier this month with Chinese President Xi Jinping ended calmly, and the U.S. Treasury Department did not label China a currency manipulator in its latest assessment.

During the first quarter, investment in fixed assets such as factories expanded 9.2 percent from a year earlier, while retail sales grew 10 percent. Industrial production rose 6.8 percent, including a stronger-than- expected 7.6 percent year-on-year gain in March.

Although exports have also shown sharp improvement, strong lending and investment figures suggest Beijing is relying on its traditional strategy of powering growth through government stimulus. China’s leaders have been trying to shift to an approach based more on consumer demand but tend to open the spending and credit taps at times when growth appears to be slowing too much.

“The question we need to ask is whether this investment-led model is sustainable as the authorities have trouble taming credit,” said Raymond Yeung and David Qu, economists at ANZ.

The latest figures indicate China’s economy is on track to meet its official growth target — a good sign for China’s communist leaders, who don’t like surprises and are preparing for a twice-a-decade party congress in the autumn to appoint new leaders.

“The 6.5 percent target this year, you could say it’s more important than ever, because of the political reshuffle later this year,” said Amy Zhuang, chief Asia analyst at Nordea Markets. “At least being able to maintain the stability in growth is very, very important for Beijing.”

On a quarter-to-quarter basis, which is how other major economies report data, the economy lost steam, expanding just 1.3 percent. That’s slower than 1.7 percent in the fourth quarter of 2016.

The economists at ANZ said such figures should be viewed cautiously because they might reflect changes in how the government made adjustments for seasonal factors.

Economists say they expect the boost from the government’s policies and the property boom to persist for a few more months before fading later in the year.

Real estate plays an outsize role in fueling growth in the wider Chinese economy by spurring knock-on demand in the manufacturing and service sectors.

House prices will likely start cooling this year as tighter restrictions finally kick in, but Beijing will probably take steps to offset that decline with more stimulus to meet its annual growth target, Zhuang said.
…

From: MeNeedIt

Parkinson’s disease was first identified 200 years ago, but so far, there is no cure. Most people have the disease for many years before it’s diagnosed, making it too late for effective treatment. So scientists are focusing on research in an effort to stop the disease before symptoms appear. VOA’s Deborah Block has more during Parkinson’s awareness month in the United States.
…

From: MeNeedIt

An art exhibition in New York highlights undocumented immigrants and the items they left behind while crossing hostile desert territory from Mexico into the United States. The show, called State of Exception, stems from the University of Michigan’s Undocumented Migration Project, and it uses only discarded objects. Celia Mendoza reports on these traces of human migration from the New School’s Parsons School of Design.
…

From: MeNeedIt

Steeped in centuries of seemingly impenetrable tea tradition, Afghanistan’s capital is getting a little coffee buzz.

Nargis Aziz Shahi says business has been increasing day by day since she opened iCafe a couple of weeks ago. Looking a little like a brick-walled Starbucks with a distinctively homey Afghan feel, it’s attracting a mostly youthful clientele drawn by free internet service and books to peruse over a cup or two.

“There were three key objectives that led me open the cafe: 1) to introduce coffee to Afghans who mostly don’t know coffee and its taste and benefits; 2) to provide a place for our youth to carry out social activities; and 3) to provide job opportunities for young people,” Shahi told VOA’s Afghan service.

Tea came to Afghanistan early

Afghanistan was introduced to tea early because of its location on ancient trade routes. The Chinese traded silk and tea for other commodities. Tea became part of the country’s hospitality for guests. Just about every family has its own recipe.

Today, Afghanistan is the world’s largest tea consumer, with each person consuming an average of almost 4.5 kilograms — more than 1,500 cups — per year in 2012. By comparison, the U.S. ranked 72nd at 0.4 kilograms per person.

Only the Russian Federation and Britain, with much larger populations, import more tea.

Coffee culture gets a start

Dr. Nabi Misdaq, adviser to President Ashraf Ghani, has visited iCafe. He regards coffee drinking as a new, enlightening culture in Afghanistan.

“It is a good beginning,” Misdaq said. “It is a profitable business, because many young people come here to read books and exchange ideas. I am sure that this will also lead to the opening of new shops.”

The cafe also serves as a place for young Afghans to carry out social and cultural activities. They come to iCafe to attend literary programs and poetry contests.

The female customers say there are few other places where they can get together and entertain themselves, but they maintain that they come to the shop to relax and enjoy.

“I am very happy that we have a coffee shop in Kabul,” said customer Samira Seerat. “It is a very good place for women to visit. There are in fact no appropriate places for women in Kabul, and Afghanistan as a whole, to visit, because our people believe that women cannot go to restaurants.”
…

From: MeNeedIt

Steeped in centuries of traditional tea drinking, Afghanistan is getting a little coffee buzz for a change. Hikmat Sorosh has more on this popular new trend from the Afghan capital, Kabul, in this story narrated by Michael Lipin, with additional reporting by Khalil Noorzaie in Herat.
…

From: MeNeedIt

Researchers in Britain have shown that genetic manipulation can prevent or slow the symptoms of Parkinson’s, in the inherited form of the disease. That’s a minority of Parkinson’s patients, but the researchers are learning more about what causes nerve cells in the brain to die. Faith Lapidus reports.
…

From: MeNeedIt

Lady Gaga will make history when she performs at the Coachella Valley Music and Arts festival this weekend, marking a decade since a solo woman has been billed as a headliner on the prestigious musical stage.

Beyonce had been slated to headline the festival in Indio, California, but backed out because she’s pregnant with twins. Bjork was the last solo female to headline Coachella in 2007, so it begs the question: Why has it taken so long?

Women have always performed at Coachella, which began Friday, since it was launched in 1999. In the last few years the number of female performers has grown, including acts that blend alternative and pop, such as Sia and Tegan & Sara, to mega genre-mashers like M.I.A., Janelle Monae and Santigold.

Coachella is known as the festival for cool kids — and musicians. That leaves little to no room for acts that dominate Top 40 radio, where women have a strong presence, from Katy Perry to Rihanna.

Halsey, the Grammy-nominated singer who is readying her second alternative album and had one of last year’s biggest pop hits with “Closer” alongside the Chainsmokers, performed at Coachella last year. The 22-year-old said women who perform alternative music are often billed as pop artists because of their sex.

“Festivals like Coachella, they pride themselves on being part of the counterculture, being tastemakers, upholding themselves to a certain standard of the artists that they include, and I think one of the problems is that female artists are so often tainted as pop artists even when they don’t necessarily intend to be,” Halsey said. “Female artists can put out the same style of a record as a male artist and when a male artist does it, it has a certain type of dignity, it has a certain type of edge … as soon as a woman puts out a record of the same caliber, it’s immediately filed as a pop record no matter what.”

Halsey said it’s something she’s experienced in her own career with the success of “Closer.”

“It was this giant pop record and immediately I was a pop artist even though I put out an alternative album, I played alternative festivals and I was on alternative radio,” she said. “As soon as [you] do one pop record it’s like the kiss of death for a female artist sometimes.”

Gary Bongiovanni, CEO of concert trade publication Pollstar, said he didn’t think the gap between male and female headliners at Coachella was calculated.

“I don’t see that there’s any sexism. There’s nothing more than trying to put together a bill of artists that the public wants to see. And we live in a world where a significant majority of the acts are either male or male-fronted bands versus females or female-fronted bands,” he said. “If you look at the level of business all of those artists do and you try to cobble together a lineup that’s going to be appealing, it’s difficult, and there are a lot of the female acts that may not lend themselves to performing in front of 60,000 or 80,000 people in an open field, versus headlining an area or more likely a theater.”

In last year’s Pollstar chart of the 100 top-grossing North America tours, women made up about 15 percent of the list, which was dominated by male acts and male-fronted bands. Only two women cracked the Top 10: Beyonce was No.1 and Adele came in fifth.

Coachella is sold out before the lineup is announced, so the festival has the luxury of picking performers instead of relying on acts to help sell tickets.

Along with Gaga, this year’s headliners include Radiohead and Kendrick Lamar, who released his hotly anticipated new album Friday. Some of the female performers include Lorde, Banks, Tove Lo, Kehlani, Nao, Kiiara and Bishop Briggs. Yukimi Nagano, who fronts Swedish band Little Dragon, is returning to Coachella for a third time.

Nagano said she was surprised that it’s been 10 years since a woman headlined the festival, adding: “I think it’s a really positive thing.”

Jason White, executive vice president of marketing at Beats by Dre, said the company is purposely, and exclusively, giving attention to women at the festival: Their space at Coachella will only feature female performers, including Erykah Badu, DJ Kiss, Ana Calderon, JCK DVY and Jasmine Solano.

“I think it really meshes incredibly well with what’s going on with Coachella because you do have Gaga, we’re excited about seeing Kehlani [and] there’s some really solid performers this year,” he said.

Halsey, who spoke over the phone Thursday as she drove to the desert to watch Coachella as a fan, said she was thrilled to see Gaga take the stage. She said the recent Super Bowl halftime performer is one of those pioneering female acts that haven’t been boxed into a genre, though she knows “the extremes [Gaga] has to go to maintain that counterculture are much greater than that of what a male artist has to do.”

“Drake is still considered a rap/rhythm artist even though he is essentially a pop artist when you look at the decisions that he makes and the climate that kind of surrounds his projects,” Halsey said.

“And when you have a female artist in the same lane, they get written off as a pop artist simply because they’re female, simply because the conversation with them, it goes to fashion, makeup or whatever, and those are questions and comments that don’t surround the brand and surround the career of a male artist.”
…

From: MeNeedIt

Julian Lennon is looking to nurture a new generation’s commitment to the environment, with a little help from a white feather.

The firstborn son of the late John Lennon has co-authored “Touch the Earth,” a picture book for kids as young as 3 about the world’s water problems, from polluted oceans to the need for clean drinking water in the developing world.

Out later this month, the book from Sky Pony Press has a group of kids loaded into a plane called the White Feather Flier as they span the globe and learn about the need for filtration, irrigation and ocean life protection. With illustrations created both by hand and computer, it’s the first of three children’s books he plans, in line with the environmental and humanitarian work of his White Feather Foundation.

“We’ve failed miserably in looking after our environment. I think this is a great way to approach children into realizing what’s at stake, and to help educate and help them make decisions about the right things to do for the future,” Lennon said in a recent interview with The Associated Press. “It’s for those with inquiring minds who are asking why?”

Lennon has taken on environmental issues in song, including his 1991 “Saltwater,” and in film, including the 2006 documentary “Whaledreamers,” covering a gathering of indigenous and tribal leaders that explores connections among whales, dolphins and humanity.

Appealing to the next generation of prospective eco-warriors grew out of his friendship with co-writer Bart Davis after the two put aside plans — for now — for the 54-year-old Lennon to write a biography. But he hasn’t completely abandoned the idea.

“I feel time’s marching on, you know. A lot of my friends and people I know are popping their clogs,” Lennon laughed. “You know, who knows what’s next. It’s in the cards in the next few years, absolutely, before it’s too late.”

So what’s up with the white feather for Lennon, the former Beatle’s son with his first wife, Cynthia? He shares the story at the back of the book.

“On the odd occasion when I saw dad he mentioned once that should he ever pass, a way he would let me know that he was OK, or that we were all going to be OK, would be in the form of a white feather,” Lennon explained. “I thought that quite peculiar. I told mum about it, too, and we just sort of went on with life.”

Later, while on tour in Australia, he was presented with a white swan feather by an aboriginal tribal elder of the Mirning people.

“It was a freaky moment, but one I took to heart immediately,” he said. “I realized that this was about stepping up to the plate now and, you know, I can sing all I want about this stuff but am I actually going to do something about it? So I spent 10 years making a documentary about the Mirning people.”

It’s also when he established his foundation, visiting Ethiopia with the head of a clean water initiative and touring schools and health clinics in Kenya. A portion of the books’ proceeds will go the foundation, which now does a range of work, including providing scholarships for girls in Kenya.

Lennon’s father was shot to death in 1980. His mother died two years ago of cancer at age 75. Her loss remains tender. Lennon dedicates the book to Cynthia, and he established the Kenya scholarships in her name.

“I talk to her every night, pretty much,” Lennon said. “She has given me the strength to carry on. Where I’m at at the moment, I feel very strong, very zenlike. I just want to do the right thing. To try to continue to be the best that I can be. That was all based around wanting to make her proud. I try to continue all the work that I do in her name.” 
…

From: MeNeedIt

More than a decade after it was proposed, India’s most ambitious tax reform measure is set to roll out in six weeks following the passage of a law that will replace a plethora of confusing levies with a single, nationwide tax.  

The new goods and services tax (GST) will unite the world’s fastest growing economy into a common market of 1.3 billion people.

The measure is seen as a major achievement for Prime Minister Narendra Modi, who struggled for two years to build a political consensus.

 The government says the GST will be implemented from July 1 after state legislatures ratify it.   

 The new tax is expected to make it vastly easier to do business as it dismantles tax checkpoints at every state border. Businesses have often complained that India’s complicated tax system leaves them grappling with a mesh of separate duties levied by each of the country’s 29 states, and goods are often stranded for hours or even days at state borders as payments are worked out.

 By making distribution more efficient and less expensive, Ankur Bisen at New Delhi based consultancy, Technopak, sees big benefits for consumer-oriented businesses, which have to move goods across state lines in the vast country. 

Another huge benefit will be increased transparency. “It will have implications on corruption because taxation regime will not be vague anymore, it will be very clearly defined,” says Bisen.

For the government, the GST is expected to improve tax compliance and draw more people into the tax net in a country where tax evasion is common. It will also make India more attractive for foreign investors by simplifying rules for a huge and increasingly attractive market.

The government estimates the new tax will boost economic growth by about half a percentage point in its first year of implementation and in the long run by as much as 2 percent.

However several economists say that the political compromises that had to be struck win approval of the new tax mean the sweeping benefits India had hoped to see may not accrue in the short run.  

Taxes will be levied at four levels – five, 12, 18 and 28 percent. Many say the 18 percent and 28 percent tax rates are too high.  

 “It could potentially have been a transformative measure if the structure of GST would have been characterized by a large base and low and single rate,” says D.K. Srivastava at consultancy Ernst and Young. But, he says, “it is going as a multiple-rate system and some of the rates are very high and the tax base is still narrow. Therefore it is a kind of a fragmented GST. ”

Despite the shortfalls, Srivastava says that “given the complications of the size of the Indian economy, it might be useful to start off with a functioning model and then go on reforming it as matters progress.”

Many also warn against a hasty implementation, saying that rushing ahead with a July 1 deadline could make it difficult to handle the transition in a country which has always struggled with bureaucratic ineptitude.

Many businesses, which had long clamored for such a tax, are asking the government for more time to prepare for the switch, saying six weeks is too little. They worry that the tax rates for various products have still be to be decided.

Others point out that the GST will be serviced by state-of-the-art technology and an electronic portal where taxpayers can register, eliminating the conventional and discretionary role of tax authorities.
…

From: MeNeedIt